Influenza virus infection drives upregulation of CD84 across a broad range of immune cells

X Jia; IJH Foo; HA McQuilten; JC Crawford; AF Cabug; D Gebregzabher; J Chou; RC Mettelman; T Novak; LA Van de Velde; RS Thwaites; AG Randolph; PG Thomas; J Xu; Z Wang; K Kedzierska; L Kedzierski; BY Chua

Journal article

Influenza virus infection drives upregulation of CD84 across a broad range of immune cells

X Jia, IJH Foo, HA McQuilten, JC Crawford, AF Cabug, D Gebregzabher, J Chou, RC Mettelman, T Novak, LA Van de Velde, RS Thwaites, AG Randolph, PG Thomas, J Xu, Z Wang, K Kedzierska, L Kedzierski, BY Chua

Clinical and Translational Immunology | Published : 2026

DOI: 10.1002/cti2.70087

Abstract

Objectives: Our previous study in hospitalised patients infected with avian A(H7N9) influenza virus identified CD84 amongst several genes associated with recovery. Yet, the correlation between CD84 and respiratory viral infection outcomes is far from established. We aimed to define CD84 dynamics in patient cohorts of respiratory disease and immune cell populations in influenza virus-infected mice. Methods: Expression dynamics of CD84 and association with previously identified correlates of severe and fatal respiratory disease outcomes, OLAH and IL18R1, were analysed in A(H7N9) and COVID-19 patient cohorts across disease severities. Using mouse models of influenza virus infection, CD84 expres..

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